Computational Glioscience
Over the last two decades, the recognition that astrocytes - the predominant type of cortical glial cells - could sense neighboring neuronal activity and release neuroactive agents, has been instrumental in the uncovering of many roles that these cells could play in brain processing and the storage...
| Συγγραφή απο Οργανισμό/Αρχή: | |
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| Άλλοι συγγραφείς: | , |
| Μορφή: | Ηλεκτρονική πηγή Ηλ. βιβλίο |
| Γλώσσα: | English |
| Έκδοση: |
Cham :
Springer International Publishing : Imprint: Springer,
2019.
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| Έκδοση: | 1st ed. 2019. |
| Σειρά: | Springer Series in Computational Neuroscience,
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| Θέματα: | |
| Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Part 1. Introduction
- A Neuron-Glial perspective for computational neuroscience
- Part 2. Calcium dynamics
- Data-driven modelling of the inositol trisphosphate receptor and its role in calcium induced calcium release
- Intracellular calcium dynamics: biophysical and simplified models
- Modeling of stochastic Ca2+ signals
- G protein-coupled receptor-mediated astrocytic Ca2+ signaling in astrocytes
- Emergence of regular and complex calcium oscillations by inositol 1,4,5-trisphosphate signaling in astrocytes
- Astrocyte networks and intercellular calcium propagation
- Part 3. Tripartite Synapse and regulation of network activity
- Tripartite synapses and regulation of synaptic plasticity
- Purinergic signaling at tripartite synapses
- Gliotransmitter exocytosis and its consequences on synaptic transmission
- Computational models of pathophysiological glial activation in CNS disorders
- Part 4. Homeostasis and Metabolic coupling
- The role of astrocytes in neurotransmitter uptake and brain metabolism
- Glutamate uptake
- Astrocytic ion dynamics: Implications for potassium buffering and liquid flow
- Constraint-Based Modeling of Metabolic Interactions in and between Astrocytes and Neurons
- Part 5. Computational Tools to Analyze and Model Astrocyte Experiments
- Computational models of astrocytes and astrocyte-neuron interactions: Characterization, reproducibility, and future perspectives
- GECIquant: semi-automated detection and quantification of astrocyte intracellular Ca2+ signals monitored with GCaMP6f
- Modeling neuron-glia interactions with the Brian 2.0 simulator.
