Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins

• Main Author: Ferraz de Paiva, Raphael Enoque (Author, http://id.loc.gov/vocabulary/relators/aut)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2018.
• Edition: 1st ed. 2018.
• Series: Springer Theses, Recognizing Outstanding Ph.D. Research,
• Subjects: Inorganic chemistry.; Organometallic chemistry .; Proteins .; Mass spectrometry.; Bioorganic chemistry.; Immunology.; Inorganic Chemistry.; Organometallic Chemistry.; Protein-Ligand Interactions.; Mass Spectrometry.; Bioorganic Chemistry.

This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the huma...

Table of Contents:

• Au(I)-phosphine series design
• Probing the Protein: Ion Mobility Spectrometry
• Probing Gold: X-ray Absorption Spectroscopy
• Probing Cells: Cytotoxicity Evaluation
• Au(III) series with k2C,N and k2N,N' ligands
• "Dual Probe" X-ray Absorption Spectroscopy.