Targeted Therapy of Colorectal Cancer Subtypes

• Corporate Author: SpringerLink (Online service)
• Other Authors: Jordan, Peter (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2018.
• Edition: 1st ed. 2018.
• Series: Advances in Experimental Medicine and Biology, 1110
• Subjects: Cancer research.; Human genetics.; Molecular biology.; Biomedical engineering.; Immunology.; Cancer Research.; Human Genetics.; Molecular Medicine.; Biomedical Engineering/Biotechnology.

In this book, a group of researchers shares their expertise on the identification and characterization of genetic colorectal cancer subtypes. They describe solid pathobiological knowledge on the distinct sporadic tumour subtypes, including the mutations found in oncogenes and tumour suppressor genes...

Table of Contents:

• Preface
• Colorectal Cancer Subtypes- the current portrait
• Targeting colon cancers with mutated BRAF and microsatellite instability
• Targeting KRAS mutant CMS3 subtype by metabolic inhibitors
• Targeting the PI3K Signalling as a Therapeutic Strategy in Colorectal Cancer
• Targeting PTEN in colorectal cancers
• Wnt signalling-targeted therapy in the CMS2 tumour subtype: a new paradigm in CRC treatment?- Impact of the microenvironment on tumour budding in colorectal cancer
• Anti-EGFR Therapy to treat metastatic colorectal cancer: not for all
• miRNAs as modulators of EGFR therapy in colorectal cancer
• Index.