Cholesterol Modulation of Protein Function Sterol Specificity and Indirect Mechanisms /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Rosenhouse-Dantsker, Avia (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt), Bukiya, Anna N. (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2019.
• Έκδοση: 1st ed. 2019.
• Σειρά: Advances in Experimental Medicine and Biology, 1115
• Θέματα: Proteomics.; Proteins .; Cell membranes .; Molecular biology.; Protein Science.; Membrane Biology.; Molecular Medicine.

In this book, renowned scientists describe the role of steroid chirality and modification of lipid membrane physical properties in the modulation of G protein-coupled receptors and ion channels. The application of commonly-used technical approaches such as mass spectrometry and nucleic magnetic reso...

Πίνακας περιεχομένων:

• Part 1. Sterol specificity in modulating protein function: 1. Chirality effect on cholesterol modulation of protein function
• 2. A critical analysis of molecular mechanisms underlying membrane cholesterol sensitivity of GPCRs
• 3. Regulation of BK channel activity by cholesterol and its derivatives
• 4. Chiral specificity of cholesterol orientation within cholesterol binding sites in inwardly rectifying potassium channels
• Part 2. Indirect modulation of protein function by cholesterol: 5. Cholesterol effect on the physical properties of lipid membranes
• 6. Effect of cholesterol on the dipole potential of lipid membranes
• 7. Mass spectroscopy imaging of cholesterol
• 8. Cholesterol-dependent gating effects on ion channels.