The Unfolded Protein Response in Cancer

• Corporate Author: SpringerLink (Online service)
• Other Authors: Clarke, Robert (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Humana, 2019.
• Edition: 1st ed. 2019.
• Series: Cancer Drug Discovery and Development,
• Subjects: Cancer research.; Cancer Research.

This volume presents state-of-the-art information on each of the arms of the unfolded protein response (UPR), how their activation/repression are regulated, integrated, and coordinated, how UPR components affect cancer cell biology and responsiveness to therapeutic interventions, and how UPR compone...

Table of Contents:

• Introduction: The Unfolded Protein Response
• Endoplasmic Reticulum Stress Signaling During Development
• Regulation of the Unfolded Protein Response and its Roles in Tumorigenesis and Cancer Therapy
• ATF4, Hypoxia and Treatment Resistance in Cancer
• Role of Protein Translation in the Unfolded Protein Response
• Roles of Spliced and Unspliced XBP1 in Breast Cancer
• The Unfolded Protein Response in Triple-Negative Breast Cancer
• The Unfolded Protein Response as an Integrator of Response to Endocrine Therapy in Estrogen Receptor Positive Breast Cancer
• Outside the Endoplasmic Reticulum: Non-Canonical GRP78 Signaling
• Autophagy and the Unfolded Protein Response in Neurodegenerative Diseases
• Index.