Structural Bioinformatics: Applications in Preclinical Drug Discovery Process

• Corporate Author: SpringerLink (Online service)
• Other Authors: Mohan, C. Gopi (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2019.
• Edition: 1st ed. 2019.
• Series: Challenges and Advances in Computational Chemistry and Physics, 27
• Subjects: Chemoinformatics.; Pharmaceutical technology.; Proteins .; Bioinformatics.; Medicinal chemistry.; Computer Applications in Chemistry.; Pharmaceutical Sciences/Technology.; Protein-Ligand Interactions.; Computational Biology/Bioinformatics.; Medicinal Chemistry.

This book reviews the advances and challenges of structure-based drug design in the preclinical drug discovery process, addressing various diseases, including malaria, tuberculosis and cancer. Written by internationally recognized researchers, this edited book discusses how the application of the va...

Table of Contents:

• Free Energy based methods to understand drug resistant mutations
• Structure-based inhibitor design for some multi-targeted drugs and its ADMET profile
• Structure-based drug design in anti-malarial agent identification
• Epigenome - the guide to genomic expression for different diseases
• Structure-based design towards Anti-Alzheimer agents
• Challenges of Structure-based drug design and discovery.