Hypoxia and Cancer Metastasis

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Gilkes, Daniele M. (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2019.
• Έκδοση: 1st ed. 2019.
• Σειρά: Advances in Experimental Medicine and Biology, 1136
• Θέματα: Cancer research.; Human genetics.; Molecular biology.; Cell biology.; Cancer Research.; Human Genetics.; Molecular Medicine.; Cell Biology.

The present book is an attempt to provide a detailed review of studies that clarify our current understanding of the role of hypoxia in the progression of primary cancer to metastatic disease. It will enable researchers to discover the critical cellular changes that occur under hypoxic conditions an...

Πίνακας περιεχομένων:

• Preface
• Hypoxia mediates tumor malignancy
• Clinical methods for quanitifying hypoxia in human tumors
• Hypoxia-induced phenotypes that mediate tumor heterogeneity
• Hypoxia and the tumors secretome
• Hypoxic signaling in angiogenesis and lymphangiogenesis
• Hypoxia induced metabolic reprogramming in cancer metastasis
• The metastatic niche and hypoxia
• Hypoxia and immune suppression
• Hypoxia-induced resistance to cancer therapy
• Therapeutic stratagies to target the hypoxic microenvironment
• Index. .