Carbonic Anhydrase as Drug Target Thermodynamics and Structure of Inhibitor Binding /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Matulis, Daumantas (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2019.
• Edition: 1st ed. 2019.
• Subjects: Molecular biology.; Medical biochemistry.; Proteins .; Medicinal chemistry.; Pharmaceutical technology.; Molecular Medicine.; Medical Biochemistry.; Protein-Ligand Interactions.; Medicinal Chemistry.; Pharmaceutical Sciences/Technology.

This book offers deep insights into the thermodynamics and molecular structures of the twelve catalytically active isoforms of human carbonic anhydrase (CA) with a particular focus on inhibitor binding for drug design. X-ray crystallographic structures in combination with enzyme kinetic testing prov...