Polymyxin Antibiotics: From Laboratory Bench to Bedside

• Corporate Author: SpringerLink (Online service)
• Other Authors: Li, Jian (Editor, http://id.loc.gov/vocabulary/relators/edt), Nation, Roger L. (Editor, http://id.loc.gov/vocabulary/relators/edt), Kaye, Keith S. (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2019.
• Edition: 1st ed. 2019.
• Series: Advances in Experimental Medicine and Biology, 1145
• Subjects: Bacteriology.; Pharmacotherapy.; Drug resistance.; Drug Resistance.

This volume is the first-ever complete treatise on polymyxins and presents the most comprehensive and up-to-date reviews of all major research and clinical topics from chemistry, microbiology, pharmacology, clinical use, to drug discovery. All chapters were written by internationally leading researc...

Table of Contents:

• Overview
• Multidrug resistant Gram-negative pathogens: the urgent need for 'old' polymyxins
• Discovery, antibacterial spectrum and chemistry
• Mechanisms of antibacterial activity
• Mechanisms of resistance
• Bioanalysis and stability of polymyxins
• In vitro pharmacodynamics and PK/PD in animals
• Antibacterial susceptibility breakpoints
• Labeling of parenteral products of colistin methanesulfonate
• Meta-analysis of polymyxin use in patients
• Clinical use of colistin
• Clinical use of polymyxin B
• Pharmacokinetics, pharmacodynamics, toxicodynamics and dosing recommendations
• Rational combinations with other antibiotics
• Toxicities in patients: management and mechanisms
• Antiendotoxin effect
• Discovery of novel polymyxin-like antibiotics
• Conclusion.