Polymyxin Antibiotics: From Laboratory Bench to Bedside
This volume is the first-ever complete treatise on polymyxins and presents the most comprehensive and up-to-date reviews of all major research and clinical topics from chemistry, microbiology, pharmacology, clinical use, to drug discovery. All chapters were written by internationally leading researc...
Συγγραφή απο Οργανισμό/Αρχή: | |
---|---|
Άλλοι συγγραφείς: | , , |
Μορφή: | Ηλεκτρονική πηγή Ηλ. βιβλίο |
Γλώσσα: | English |
Έκδοση: |
Cham :
Springer International Publishing : Imprint: Springer,
2019.
|
Έκδοση: | 1st ed. 2019. |
Σειρά: | Advances in Experimental Medicine and Biology,
1145 |
Θέματα: | |
Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Overview
- Multidrug resistant Gram-negative pathogens: the urgent need for 'old' polymyxins
- Discovery, antibacterial spectrum and chemistry
- Mechanisms of antibacterial activity
- Mechanisms of resistance
- Bioanalysis and stability of polymyxins
- In vitro pharmacodynamics and PK/PD in animals
- Antibacterial susceptibility breakpoints
- Labeling of parenteral products of colistin methanesulfonate
- Meta-analysis of polymyxin use in patients
- Clinical use of colistin
- Clinical use of polymyxin B
- Pharmacokinetics, pharmacodynamics, toxicodynamics and dosing recommendations
- Rational combinations with other antibiotics
- Toxicities in patients: management and mechanisms
- Antiendotoxin effect
- Discovery of novel polymyxin-like antibiotics
- Conclusion.