Endotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems

• Corporate Author: SpringerLink (Online service)
• Other Authors: Williams, Kevin L. (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2019.
• Edition: 1st ed. 2019.
• Subjects: Pharmaceutical technology.; Medical microbiology.; Pharmaceutical Sciences/Technology.; Medical Microbiology.

Endotoxin detection and control is a dynamic area of applied science that touches a vast number of complex subjects. The intersection of test activities includes the use of an ancient blood system from an odd "living fossil" (Limulus). It is used to detect remnants of the most primitive an...

Table of Contents:

• Introduction
• Section I Pharma
• Historical Perspectives
• Risk, Control and Compliance.
• Sterility and Beyond
• LVPs and SMDs
• Specification Determination
• Static and Dynamic Models (Biodiversity and Heterogeneity)
• Test Development and Validation
• Diminishing Analytics
• Control in Biologics Manufacture
• Depyrogenation and Medical Devices
• Nanoparticles / Problematic Drug Types
• New Frontiers
• Section II Limulus
• Evolution, a Living Fossil and Other Model Arthropods
• Water, Water Everywhere
• Survival and Mass Extinction Events
• Limulus Soup / Hemolymph
• Is Innate Modeling Enough?
• A Foreboding
• Section III Mammalian
• Innate is Inborn
• The Host Response: Fever and Inflammation
• . Parallel Immune Systems: Architecture and Mechanisms
• Structural Change is Functional Change (Hand in Glove)
• Endotoxin and Adjuvanticity in Vaccinology
• Advances in Diagnostics
• The Big S.