The mRNA Metabolism in Human Disease

• Corporate Author: SpringerLink (Online service)
• Other Authors: Romão, Luísa (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2019.
• Edition: 1st ed. 2019.
• Series: Advances in Experimental Medicine and Biology, 1157
• Subjects: Human genetics.; Cancer research.; Molecular biology.; Nucleic acids.; Human Genetics.; Cancer Research.; Molecular Medicine.; Nucleic Acid Chemistry.

The eukaryotic gene expression pathway involves a number of interlinked steps, with messenger RNA (mRNA) being the key intermediate. The precursor mRNA is transcribed from DNA, processed by removal of introns and addition of the cap structure and the poly(A) tail. The mature mRNA is then exported to...

Table of Contents:

• Prelims
• Networks of mRNA processing and alternative splicing regulation in health and disease
• The diverse roles of RNA-binding proteins in glioma development
• Nonsense-mediated mRNA decay in development, stress and cancer
• Implication of mRNA degradation disorders on human DISease: focus on DIS3 and DIS3-like enzymes
• Translational regulation by upstream open reading frames and human diseases
• Alternative mechanisms of mRNA translation initiation in cellular stress response and cancer
• RNA therapeutics: how far have we gone? Index.