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03547nam a2200541 4500 |
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978-3-030-21454-8 |
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DE-He213 |
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20191025092052.0 |
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cr nn 008mamaa |
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190831s2019 gw | s |||| 0|eng d |
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|a 9783030214548
|9 978-3-030-21454-8
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|a 10.1007/978-3-030-21454-8
|2 doi
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|a 615
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|a Calcitonin Gene-Related Peptide (CGRP) Mechanisms
|h [electronic resource] :
|b Focus on Migraine /
|c edited by Susan D. Brain, Pierangelo Geppetti.
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| 250 |
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|a 1st ed. 2019.
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| 264 |
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|a Cham :
|b Springer International Publishing :
|b Imprint: Springer,
|c 2019.
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| 300 |
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|a VII, 192 p. 23 illus., 17 illus. in color.
|b online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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|a text file
|b PDF
|2 rda
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|a Handbook of Experimental Pharmacology,
|x 0171-2004 ;
|v 255
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| 505 |
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|a 1. CGRP Discovery and Timeline -- 2. CGRP Receptor Biology: Is There More Than One Receptor? -- 3. The Structure of the CGRP and Related Receptors -- 4. CGRP Receptor Signalling Pathways -- 5. Pathways of CGRP Release from Primary Sensory Neurons -- 6. CGRP in Animal Models of Migraine -- 7. CGRP in Human Models of Migraine -- 8. Role of CGRP in Migraine -- 9. Understanding CGRP and Cardiovascular Risk -- 10. CGRP and Painful Pathologies other than Headache -- 11. Calcitonin Gene-Related Peptide Antagonists and Therapeutic Antibodies.
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| 520 |
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|a This book is designed to focus on the role of Calcitonin Gene-Related Peptide (CGRP) in health and disease. This peptide, originally discovered in the 1980s as a sensory neuropeptide with cardiovascular effects, is now known to play a distinct role in the pain processing of migraine. The various chapters address the origin, localization and function of CGRP and its receptor in the peripheral nervous system, in the cardiovascular system, and in other tissues and organs. Further attention is paid to the drug discovery pathway where recent findings show the beneficial effect of small molecule antagonists of the CGRP receptors for the relief of the migraine attack and of monoclonal antibodies against CGRP or the CGRP receptor for migraine prevention. .
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| 650 |
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|a Pharmacology.
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| 650 |
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|a Neurology .
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| 650 |
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|a Pain medicine.
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| 650 |
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|a Neurosciences.
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| 650 |
1 |
4 |
|a Pharmacology/Toxicology.
|0 http://scigraph.springernature.com/things/product-market-codes/B21007
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| 650 |
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|a Neurology.
|0 http://scigraph.springernature.com/things/product-market-codes/H36001
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| 650 |
2 |
4 |
|a Pain Medicine.
|0 http://scigraph.springernature.com/things/product-market-codes/H47003
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| 650 |
2 |
4 |
|a Neurosciences.
|0 http://scigraph.springernature.com/things/product-market-codes/B18006
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| 700 |
1 |
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|a Brain, Susan D.
|e editor.
|4 edt
|4 http://id.loc.gov/vocabulary/relators/edt
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| 700 |
1 |
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|a Geppetti, Pierangelo.
|e editor.
|4 edt
|4 http://id.loc.gov/vocabulary/relators/edt
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 776 |
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8 |
|i Printed edition:
|z 9783030214531
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| 776 |
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8 |
|i Printed edition:
|z 9783030214555
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| 776 |
0 |
8 |
|i Printed edition:
|z 9783030214562
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| 830 |
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|a Handbook of Experimental Pharmacology,
|x 0171-2004 ;
|v 255
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| 856 |
4 |
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|u https://doi.org/10.1007/978-3-030-21454-8
|z Full Text via HEAL-Link
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| 912 |
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|a ZDB-2-SBL
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| 950 |
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|a Biomedical and Life Sciences (Springer-11642)
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