Calcitonin Gene-Related Peptide (CGRP) Mechanisms Focus on Migraine /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Brain, Susan D. (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt), Geppetti, Pierangelo (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2019.
• Έκδοση: 1st ed. 2019.
• Σειρά: Handbook of Experimental Pharmacology, 255
• Θέματα: Pharmacology.; Neurology .; Pain medicine.; Neurosciences.; Pharmacology/Toxicology.; Neurology.; Pain Medicine.

This book is designed to focus on the role of Calcitonin Gene-Related Peptide (CGRP) in health and disease. This peptide, originally discovered in the 1980s as a sensory neuropeptide with cardiovascular effects, is now known to play a distinct role in the pain processing of migraine. The various cha...

Πίνακας περιεχομένων:

• 1. CGRP Discovery and Timeline
• 2. CGRP Receptor Biology: Is There More Than One Receptor?
• 3. The Structure of the CGRP and Related Receptors
• 4. CGRP Receptor Signalling Pathways
• 5. Pathways of CGRP Release from Primary Sensory Neurons
• 6. CGRP in Animal Models of Migraine
• 7. CGRP in Human Models of Migraine
• 8. Role of CGRP in Migraine
• 9. Understanding CGRP and Cardiovascular Risk
• 10. CGRP and Painful Pathologies other than Headache
• 11. Calcitonin Gene-Related Peptide Antagonists and Therapeutic Antibodies.