Bile Acids and Their Receptors
This book focusses on the latest results related to the field of bile acids as signaling molecules and describes how these receptors have become a major pharmacological target. It covers all major areas of research in this field, from genetics, chemistry, in silico modeling, molecular biology to cli...
Συγγραφή απο Οργανισμό/Αρχή: | |
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Άλλοι συγγραφείς: | , |
Μορφή: | Ηλεκτρονική πηγή Ηλ. βιβλίο |
Γλώσσα: | English |
Έκδοση: |
Cham :
Springer International Publishing : Imprint: Springer,
2019.
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Έκδοση: | 1st ed. 2019. |
Σειρά: | Handbook of Experimental Pharmacology,
256 |
Θέματα: | |
Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Preface
- Part 1. Bile acids as signaling molecules and their receptors
- 1. A short history of bile acid pharmacology
- 2. Bile acids activated receptors: a review of GPBAR1 (TGR5) and other G-protein-coupled receptors
- 3. Bile acid activated receptors: a review of FXR and other Nuclear receptors
- 4. The intestinal enterokine fibroblast growth factor 15/19 in bile acid metabolism
- 5. Signaling from intestine to the host. How bile acids regulate intestinal and liver immunity
- Part 2. General pharmacology of bile acid activated receptors and their ligands
- 6. Modeling of bile acid activated receptors as a tool for pharmacological development
- 7. Chemistry and pharmacology of GPBAR1 and FXR selective agonists, dual agonists and antagonists
- 8. Non steroidal FXR ligands: current status and clinical applications
- 9. Intestinal selective FXR agonists and their potential in treating liver and metabolic diseases
- Part 3. Bile acids and their derivatives as drugs
- 10. UDCA, Nor-UDCA and T-UDCA: a review of their mechanisms of action and clinical applications
- 11. Chenodeoxycholic acid: an update on its therapeutic appplications and safety profile
- 12. Obeticholic acid: a review of its mechanisms of action and clinical applications
- Part 4. Bile acid activated receptors as therapeutic targets
- 13. Targeting FXR in cholestasis
- 14. FXR agonists for the treatment of NASH and other metabolic disorders
- 15. Targeting bile acids activated receptors in bariatric surgery.