Bile Acids and Their Receptors

• Corporate Author: SpringerLink (Online service)
• Other Authors: Fiorucci, Stefano (Editor, http://id.loc.gov/vocabulary/relators/edt), Distrutti, Eleonora (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2019.
• Edition: 1st ed. 2019.
• Series: Handbook of Experimental Pharmacology, 256
• Subjects: Pharmacology.; Gastroenterology .; Hepatology.; Endocrinology .; Pharmacology/Toxicology.; Gastroenterology.; Endocrinology.

This book focusses on the latest results related to the field of bile acids as signaling molecules and describes how these receptors have become a major pharmacological target. It covers all major areas of research in this field, from genetics, chemistry, in silico modeling, molecular biology to cli...

Table of Contents:

• Preface
• Part 1. Bile acids as signaling molecules and their receptors
• 1. A short history of bile acid pharmacology
• 2. Bile acids activated receptors: a review of GPBAR1 (TGR5) and other G-protein-coupled receptors
• 3. Bile acid activated receptors: a review of FXR and other Nuclear receptors
• 4. The intestinal enterokine fibroblast growth factor 15/19 in bile acid metabolism
• 5. Signaling from intestine to the host. How bile acids regulate intestinal and liver immunity
• Part 2. General pharmacology of bile acid activated receptors and their ligands
• 6. Modeling of bile acid activated receptors as a tool for pharmacological development
• 7. Chemistry and pharmacology of GPBAR1 and FXR selective agonists, dual agonists and antagonists
• 8. Non steroidal FXR ligands: current status and clinical applications
• 9. Intestinal selective FXR agonists and their potential in treating liver and metabolic diseases
• Part 3. Bile acids and their derivatives as drugs
• 10. UDCA, Nor-UDCA and T-UDCA: a review of their mechanisms of action and clinical applications
• 11. Chenodeoxycholic acid: an update on its therapeutic appplications and safety profile
• 12. Obeticholic acid: a review of its mechanisms of action and clinical applications
• Part 4. Bile acid activated receptors as therapeutic targets
• 13. Targeting FXR in cholestasis
• 14. FXR agonists for the treatment of NASH and other metabolic disorders
• 15. Targeting bile acids activated receptors in bariatric surgery.