Structure and Function of GPCRs

• Corporate Author: SpringerLink (Online service)
• Other Authors: Lebon, Guillaume (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2019.
• Edition: 1st ed. 2019.
• Series: Topics in Medicinal Chemistry, 30
• Subjects: Medicinal chemistry.; Pharmaceutical technology.; Spectroscopy.; Medicinal Chemistry.; Pharmaceutical Sciences/Technology.; Spectroscopy/Spectrometry.

This book introduces readers to the latest advances in G protein-coupled receptor (GPCR) biology. It reviews our current understanding of the structural basis of ligand binding and allosteric mechanisms, following a decade of technological breakthroughs. Several examples of structure-based drug disc...

Table of Contents:

• Structures of Non-rhodopsin GPCRs Elucidated Through X-Ray Crystallography
• NMR Spectroscopy for the Characterization of GPCR Energy Landscapes
• Structure and Activation Mechanism of GPCRs
• Structure-Based Discovery of GPCR Ligands from Crystal Structures and Homology Models
• Integration on Ligand and Structure Based Approaches in GPCRs
• Biased Agonist Pharmacochaperones: Small Molecules in the Toolbox for Selectively Modulating GPCR Activity
• Endosomal PTH Receptor Signaling Through cAMP and Its Consequence for Human Medicine
• Structure and Function Studies of GPCRs by Site-Specific Incorporation of Unnatural Amino Acids
• Fluorescent-Based Strategies to Investigate G Protein-Coupled Receptors: Evolution of the Techniques to a Better Understanding
• Modulation of Metabotropic Glutamate Receptors by Orthosteric, Allosteric, and Light-Operated Ligands. .