HCV: The Journey from Discovery to a Cure Volume I /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Sofia, Michael J. (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2019.
• Έκδοση: 1st ed. 2019.
• Σειρά: Topics in Medicinal Chemistry, 31
• Θέματα: Medicinal chemistry.; Virology.; Medical biochemistry.; Bioorganic chemistry.; Pharmaceutical technology.; Medicinal Chemistry.; Medical Biochemistry.; Bioorganic Chemistry.; Pharmaceutical Sciences/Technology.

Hepatitis C is a liver disease caused by the hepatitis C virus (HCV) and infects approximately 75 million individuals worldwide. It is also one of the major causes of liver cancer and liver transplants. The elucidation of the HCV genome, and the development of a whole cell system to study the virus...

Πίνακας περιεχομένων:

• Identification of the virus, the medical need and clearing the blood supply
• Mapping the HCV genome
• The molecular virology of HCV
• The development of the HCV replicon system
• The Evolution of IFN therapy for HCV
• Evolution of HCV NS5B Non-Nucleoside Inhibitors
• Evolution of HCV NS5B Nucleoside & Nucleotide Inhibitors
• Discovery and Development of Sofosbuvir
• Discovery of Beclabuvir
• Discovery of Dasabuvir
• Evolution of HCV NS3/4 protease inhibitors
• Discovery and Development of Telaprevir
• Discovery and Development of Boceprevir
• Discovery and Development of Asunaprevir.-Discovery and Development of Grazoprevir
• Discovery and Development of Simeprevir
• Discovery and Development of Paritaprevir & Glecaprevir.