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03408nam a2200517 4500 |
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978-3-030-31053-0 |
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DE-He213 |
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20191026221520.0 |
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cr nn 008mamaa |
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190903s2019 gw | s |||| 0|eng d |
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|a 9783030310530
|9 978-3-030-31053-0
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|a 10.1007/978-3-030-31053-0
|2 doi
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|a 616.079
|2 23
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|a Fc Mediated Activity of Antibodies
|h [electronic resource] :
|b Structural and Functional Diversity /
|c edited by Jeffrey V. Ravetch, Falk Nimmerjahn.
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| 250 |
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|a 1st ed. 2019.
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| 264 |
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1 |
|a Cham :
|b Springer International Publishing :
|b Imprint: Springer,
|c 2019.
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| 300 |
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|a VII, 150 p. 14 illus., 12 illus. in color.
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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|a text file
|b PDF
|2 rda
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| 490 |
1 |
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|a Current Topics in Microbiology and Immunology,
|x 0070-217X ;
|v 423
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| 505 |
0 |
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|a IgG Fc receptors: evolutionary considerations -- Role of FcgRs in Antibody Based Cancer Therapy -- Anti-inflammatory Activity of IgG-Fc -- IgG Fc glycosylation in human immunity -- IgE Glycosylation in Health and Disease -- Immune Complex Vaccination -- Fc receptors in anti-microbial protection.
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| 520 |
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|a This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer immunotherapy, and focuses on how IgG glycosylation regulates IgG and IgE activity in autoimmunity, allergy and infection. In closing, it presents strategies for developing novel antibody-based vaccination approaches. The book is intended for a very broad readership, including graduate students, postdocs and principal investigators with a basic grasp of immunology.
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| 650 |
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|a Immunology.
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| 650 |
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|a Cancer research.
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| 650 |
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|a Infectious diseases.
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| 650 |
1 |
4 |
|a Immunology.
|0 http://scigraph.springernature.com/things/product-market-codes/B14000
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| 650 |
2 |
4 |
|a Cancer Research.
|0 http://scigraph.springernature.com/things/product-market-codes/B11001
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| 650 |
2 |
4 |
|a Infectious Diseases.
|0 http://scigraph.springernature.com/things/product-market-codes/H33096
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| 700 |
1 |
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|a Ravetch, Jeffrey V.
|e editor.
|4 edt
|4 http://id.loc.gov/vocabulary/relators/edt
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| 700 |
1 |
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|a Nimmerjahn, Falk.
|e editor.
|4 edt
|4 http://id.loc.gov/vocabulary/relators/edt
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 776 |
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8 |
|i Printed edition:
|z 9783030310523
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| 776 |
0 |
8 |
|i Printed edition:
|z 9783030310547
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| 776 |
0 |
8 |
|i Printed edition:
|z 9783030310554
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| 830 |
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|a Current Topics in Microbiology and Immunology,
|x 0070-217X ;
|v 423
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| 856 |
4 |
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|u https://doi.org/10.1007/978-3-030-31053-0
|z Full Text via HEAL-Link
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| 912 |
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|a ZDB-2-SBL
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| 950 |
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|a Biomedical and Life Sciences (Springer-11642)
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