The Biology of mRNA: Structure and Function

• Corporate Author: SpringerLink (Online service)
• Other Authors: Oeffinger, Marlene (Editor, http://id.loc.gov/vocabulary/relators/edt), Zenklusen, Daniel (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2019.
• Edition: 1st ed. 2019.
• Series: Advances in Experimental Medicine and Biology, 1203
• Subjects: Molecular biology.; Gene expression.; Proteins .; Neurosciences.; Posttranslational modification.; Molecular Medicine.; Gene Expression.; Protein-Ligand Interactions.; Posttranslational Modification.

 The book provides an overview on the different aspects of gene regulation from an mRNA centric viewpoint, including how mRNA is assembled and self-assembles in a complex consisting of RNA and proteins, and how its ability to be translated at the right time and space depends on many processes acting on the mRNAs, leading to a properly folded complex. This book shows how new technologies have led to a better understanding of these processes and their connected diseases. The book is written for scientists in fundamental and applied biomedical research working on different aspects of gene regulation. It is also targeted to an audience that is not implicated in these fields directly, but wants to gain a better understanding of mRNA biology. 

 Regulation of co-transcriptional mRNP assembly -- mRNA export through the NPC -- Roles of mRNA modifications in gene regulation -- Studying mRNPs using single molecule approaches -- Difference between mRNPs and lncRNAs? -- RNPs and/or sequence motives in mRNA localization -- mRNP structure -- New RNA binding proteins: mRNP composition -- Aggregation of repeats RNAs in neurodegenerative diseases -- mRNA structural organization and translation -- How to decide to make an mRNA - degradation -- Methods to study mRNP composition -- mRNA-DNA kisses - R-loops -- Forms of mRNA editing and their role in disease.