HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design A Review of 20 Years of Research /
This book gathers a series of pivotal papers on the development of an HIV/AIDS vaccine published in the last two decades. Accompanied by extensive comments putting the material into an up-to-date context, all three parts of the book offer a broad overview of the numerous unsuccessful attempts made i...
| Κύριος συγγραφέας: | |
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| Συγγραφή απο Οργανισμό/Αρχή: | |
| Μορφή: | Ηλεκτρονική πηγή Ηλ. βιβλίο |
| Γλώσσα: | English |
| Έκδοση: |
Cham :
Springer International Publishing : Imprint: Springer,
2019.
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| Έκδοση: | 1st ed. 2019. |
| Θέματα: | |
| Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Part I.Immunochemistry
- 1 What is a B cell epitope
- 2 Molecular design versus empirical discovery in peptide-based vaccines. Coming to terms with fuzzy recognition sites and ill-defined structure-function relationships in immunology
- 3 Synthetic Peptide Vaccines and the Search for Neutralization B Cell Epitopes
- 4 Specificity, polyspecificity, and heterospecificity of antibody‐antigen recognition
- Part II. Reductionism
- 5 Reductionism and the search for structure-function relationships in antibody molecules
- 6 Reductionism and complexity in molecular biology
- 7 Editorial: Biological complexity emerges from the ashes of genetic reductionism
- 8 The rational design of biological complexity: A deceptive metaphor., 9 Basic research in HIV vaccinology is hampered by reductionist thinking
- 10 Commentary: Basic Research in HIV Vaccinology Is Hampered by Reductionist Thinking
- 11 Nature and Consequences of Biological Reductionism for the Immunological Study of Infectious Diseases., Part III. Vaccinology
- 12 Limitations to the structure‐based design of HIV‐1 vaccine immunogens
- 13 Two meanings of reverse vaccinology and the empirical nature of vaccine science
- 14 Requirements for empirical immunogenicity trials, rather than structure-based design, for developing an effective HIV vaccine
- 15 Paradigm Changes and the Future of HIV Vaccine Research: A Summary of a Workshop Held in Baltimore on 20 November 2013
- 16 Editorial: Paradigm changes are required in HIV vaccine research
- 17 An outdated notion of antibody specificity is one of the major detrimental assumptions of the structure-based reverse vaccinology paradigm, which prevented it from helping to develop an effective HIV-1 vaccine
- 18 More surprises in the development of an HIV vaccine
- 19 Why Does the Molecular Structure of Broadly Neutralizing Monoclonal Antibodies Isolated from Individuals Infected with HIV-1 not Inform the Rational Design of an HIV-1 Vaccine?
- 20 Old and New Concepts and Strategies in HIV Vaccinology: A Report from a Workshop held in Rome on 17 June 2016
- 21 Structure-Based Reverse Vaccinology Failed in the Case of HIV Because it Disregarded Accepted Immunological Theory
- 22 Immune systems rather than antigenic epitopes elicit and produce protective antibodies against HIV
- 23 Development of a Preventive HIV Vaccine Requires Solving Inverse Problems Which Is Unattainable by Rational Vaccine Design
- 24 Viral species, viral genomes and HIV vaccine design: is the rational design of biological complexity a utopia?
