Endothelial Dysfunction and Inflammation

• Corporate Author: SpringerLink (Online service)
• Other Authors: Dauphinee, Shauna (Editor), Karsan, Aly (Editor)
• Format: Electronic eBook
• Language: English
• Published: Basel : Springer Basel, 2010.
• Series: Progress in Inflammation Research
• Subjects: Medicine.; Immunology.; Pharmacology.; Medical biochemistry.; Cell biology.; Oxidative stress.; Biomedicine.; Oxidative Stress.; Medical Biochemistry.; Cell Biology.; Pharmacology/Toxicology.

Endothelial dysfunction is broadly defined as a disruption of the balance between vasoactive mediators and a propensity towards an inflammatory state. This volume provides an overview of the fields of endothelial dysfunction and inflammation through the discussion of topics ranging from the molecula...

Table of Contents:

• Endothelial activation and dysfunction in sepsis
• Heterogeneity in responses of microvascular endothelial cells during inflammation
• Oxidative stress and endothelial dysfunction
• Post-translational regulation of eNOS activity in inflammation
• Endothelial dysfunction in pulmonary hypertension
• Endothelial dysfunction in systemic hypertension
• Sphingosine-1-phosphate as a mediator of endothelial dysfunction during inflammation
• Dissecting TNF-TNFR1/TNFR2 signaling pathways in vasculature
• AGE-RAGE signalling in endothelial dysfunction and atherosclerosis in diabetes
• Regional predisposition to atherosclerosis – An interplay between local hemodynamics, endothelial cells and resident intimal dendritic cells
• Inflammation and endothelial dysfunction with aging
• Clinical approaches to assess endothelial function in vivo
• Therapeutic approaches towards targeting endothelial dysfunction.