Glutamate-based Therapies for Psychiatric Disorders

• Corporate Author: SpringerLink (Online service)
• Other Authors: Skolnick, Phil (Editor)
• Format: Electronic eBook
• Language: English
• Published: Basel : Birkhäuser Basel : Imprint: Birkhäuser, 2010.
• Series: Milestones in Drug Therapy
• Subjects: Medicine.; Neurosciences.; Pharmacology.; Psychiatry.; Psychopharmacology.; Medicine & Public Health.; Pharmacology/Toxicology.

Both metabotropic and ionotropic glutamate receptors present attractive “druggable” targets in treating disorders of the central nervous system. There has been a dramatic shift in the focus of glutamate-based therapies away from neurologic disorders such as stroke and traumatic brain injury to the t...

Table of Contents:

• N-Methyl-d-Aspartate (NMDA) Antagonists for the Treatment of Depression
• Ionic Glutamate Modulators in Depression (Zinc, Magnesium)
• Positive Allosteric Modulation of AMPA Receptors: A Novel Potential Antidepressant Therapy
• Glutamatergic Modulators for the Treatment of Major Depressive Disorder: Metabotropic Glutamate Receptors
• Positive Modulation of AMPA Receptors as a Broad-Spectrum Strategy for Treating Neuropsychiatric Disorders
• Activation of Group II Metabotropic Glutamate Receptors (mGluR2 and mGluR3) as a Novel Approach for Treatment of Schizophrenia
• mGluR1 Negative Allosteric Modulators: An Alternative Metabotropic Approach for the Treatment of Schizophrenia
• Metabotropic Glutamate Receptors as Targets for the Treatment of Drug and Alcohol Dependence
• Metabotropic Approaches to Anxiety.