|
|
|
|
| LEADER |
03985nam a22005415i 4500 |
| 001 |
978-3-0346-0277-8 |
| 003 |
DE-He213 |
| 005 |
20151030031121.0 |
| 007 |
cr nn 008mamaa |
| 008 |
101109s2011 sz | s |||| 0|eng d |
| 020 |
|
|
|a 9783034602778
|9 978-3-0346-0277-8
|
| 024 |
7 |
|
|a 10.1007/978-3-0346-0277-8
|2 doi
|
| 040 |
|
|
|d GrThAP
|
| 050 |
|
4 |
|a QR46
|
| 072 |
|
7 |
|a MMFM
|2 bicssc
|
| 072 |
|
7 |
|a MED052000
|2 bisacsh
|
| 082 |
0 |
4 |
|a 616.9041
|2 23
|
| 245 |
1 |
0 |
|a Replicating Vaccines
|h [electronic resource] :
|b A New Generation /
|c edited by Philip R. Dormitzer, Christian W. Mandl, Rino Rappuoli.
|
| 250 |
|
|
|a First.
|
| 264 |
|
1 |
|a Basel :
|b Springer Basel,
|c 2011.
|
| 300 |
|
|
|a XIII, 447 p.
|b online resource.
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a computer
|b c
|2 rdamedia
|
| 338 |
|
|
|a online resource
|b cr
|2 rdacarrier
|
| 347 |
|
|
|a text file
|b PDF
|2 rda
|
| 490 |
1 |
|
|a Birkhäuser Advances in Infectious Diseases
|
| 505 |
0 |
|
|a SECTION 1: Today’s Live Attenuated Vaccines -- Live Vaccines and their Role in Modern Vaccinology -- Live Attenuated Vaccines: Influenza, Rotavirus and Varicella Zoster -- Classical Live Viral Vaccines -- SECTION 2: Genetically Attenuated Micro-Organisms as Vaccines -- Recombinant Live Vaccines to Protect Against the Severe Acute Respiratory Syndrome Coronavirus -- Live Attenuated Shigella Vaccines. Is encouraging good enough? -- New generation BCG vaccines -- SECTION 3: Manipulating Host-Pathogen Interactions to Make Vaccines -- Basic Science Paves the Way to Novel Safe and Effective Pestivirus Vaccines -- Live Attenuated Influenza Virus Vaccines: NS1 Truncation as an Approach to Virus Attenuation Approaches -- An Attenuated Herpes implex Virus 1 Live Virus Vaccine Candidate that is Replication Competent but Defective in Epithelial Cell to Cell and Neuronal Spread -- RSV Deletion Mutant – Innate Immunity -- Live Attenuated Cholera Vaccines: Flagella and Reactogenicity -- SECTION 4: New Types of Replicating Vaccines -- Replication-defective Herpes simplex Virus Mutant Strains as Genital Herpes Vaccines and Vaccine Vectors -- Nucleic Acid-Based Infectious and Pseudo-Infectious Flavivirus Vaccines -- Application of Cleavage Activation Mutants of Influenza Virus as Live Vaccines -- Alphavirus Particle-based Vaccine Vectors -- Recombinant, Chimeric, Live, Attenuated Vaccines against Flaviviruses and Alphaviruses.
|
| 520 |
|
|
|a Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new types of replicating vaccines, such as vectored vaccines, single-round infectious vaccines and replicon vaccines. This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines.
|
| 650 |
|
0 |
|a Medicine.
|
| 650 |
|
0 |
|a Immunology.
|
| 650 |
|
0 |
|a Medical microbiology.
|
| 650 |
|
0 |
|a Vaccines.
|
| 650 |
|
0 |
|a Virology.
|
| 650 |
1 |
4 |
|a Biomedicine.
|
| 650 |
2 |
4 |
|a Medical Microbiology.
|
| 650 |
2 |
4 |
|a Vaccine.
|
| 650 |
2 |
4 |
|a Immunology.
|
| 650 |
2 |
4 |
|a Virology.
|
| 700 |
1 |
|
|a Dormitzer, Philip R.
|e editor.
|
| 700 |
1 |
|
|a Mandl, Christian W.
|e editor.
|
| 700 |
1 |
|
|a Rappuoli, Rino.
|e editor.
|
| 710 |
2 |
|
|a SpringerLink (Online service)
|
| 773 |
0 |
|
|t Springer eBooks
|
| 776 |
0 |
8 |
|i Printed edition:
|z 9783034602761
|
| 830 |
|
0 |
|a Birkhäuser Advances in Infectious Diseases
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1007/978-3-0346-0277-8
|z Full Text via HEAL-Link
|
| 912 |
|
|
|a ZDB-2-SBL
|
| 950 |
|
|
|a Biomedical and Life Sciences (Springer-11642)
|
