Treatment and Prevention of Malaria Antimalarial Drug Chemistry, Action and Use /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Staines, Henry M. (Editor), Krishna, Sanjeev (Editor)
• Format: Electronic eBook
• Language: English
• Published: Basel : Springer Basel : Imprint: Springer, 2012.
• Series: Milestones in Drug Therapy
• Subjects: Medicine.; Immunology.; Drug resistance.; Parasitology.; Pharmacology.; Infectious diseases.; Biomedicine.; Pharmacology/Toxicology.; Infectious Diseases.; Drug Resistance.

Malaria has defeated previous efforts at eradication and remains a massive global public health problem despite being readily preventable and treatable. It is a devastating disease that also extracts huge economic costs from the poorest countries in endemic regions.   Starting with an overview of th...

Table of Contents:

• Antimalarial drugs and the control and elimination of malaria
• 4-Aminoquinolines: chloroquine, amodiaquine and next generation analogues
• Cinchona alkaloids: quinine and quinidine
• 8-Aminoquinolines: primaquine and tafenoquine
• Other 4-methanolquinolines, amyl alcohols and phentathrenes: mefloquine, lumefantrine, halofantrine, piperaquine and pyronaridine
• Antifolates: pyrimethamine, proguanil, sulphadoxine and dapsone
• Naphthoquinones: atovaquone, and other antimalarials targeting mitochondrial functions
• Non-antifolate antibiotics: clindamycin, doxycycline, azithromycin and fosmidomycin
• Artemisinins: artemisinin, dihydroartemisinin, artemether, arteether and artesunate
• Second generation peroxides: the OZs and artemisone
• Combination therapy in light of emerging artemisinin resistance
• New medicines to combat malaria: an overview of the global pipeline of therapeutics
• Molecular markers of Plasmodium resistance to antimalarials
• Prevention of malaria
• Malaria diagnostics: lighting the path.