Ibuprofen: Pharmacology, Therapeutics and Side Effects

Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions, even in a low-dose form for over-the-counter (OTC), non-prescription sale. Over the past 40 years, ibuprofen has been proven to be as safe or safer and just as...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριος συγγραφέας: Rainsford, K. D. (Συγγραφέας)
Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Basel : Springer Basel : Imprint: Springer, 2012.
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
LEADER 03124nam a22004575i 4500
001 978-3-0348-0496-7
003 DE-He213
005 20151125231518.0
007 cr nn 008mamaa
008 130131s2012 sz | s |||| 0|eng d
020 |a 9783034804967  |9 978-3-0348-0496-7 
024 7 |a 10.1007/978-3-0348-0496-7  |2 doi 
040 |d GrThAP 
050 4 |a RM1-950 
072 7 |a MMG  |2 bicssc 
072 7 |a MED071000  |2 bisacsh 
082 0 4 |a 615  |2 23 
100 1 |a Rainsford, K. D.  |e author. 
245 1 0 |a Ibuprofen: Pharmacology, Therapeutics and Side Effects  |h [electronic resource] /  |c by K. D. Rainsford. 
264 1 |a Basel :  |b Springer Basel :  |b Imprint: Springer,  |c 2012. 
300 |a XX, 243 p. 40 illus., 23 illus. in color.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
347 |a text file  |b PDF  |2 rda 
505 0 |a Introduction -- Biodisposition in relation to actions -- Mechanisms of inflammation and sites of action of NSAIDs -- Clinical efficacy -- Drug derivatives and formulations -- General safety profile -- Gastro-intestinal toxicity -- Cardiovascular safety -- Renal toxicity -- Hepatic toxicity -- Other adverse reactions -- Global assessment of adverse reactions & human toxicology -- Overall assessment. 
520 |a Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions, even in a low-dose form for over-the-counter (OTC), non-prescription sale. Over the past 40 years, ibuprofen has been proven to be as safe or safer and just as effective as established non-steroidal anti-inflammatory drugs (NSAIDs) or coxibs. This book reviews the pharmacology, clinical uses and adverse effects of ibuprofen. Its disposition and unique modes of action in relation to clinical effects are discussed as well as various formulations and the impact of food and other variables on its actions and gastro-intestinal safety. The use of combinations of ibuprofen with other drugs (e.g. paracetamol, codeine and caffeine) are critically assessed. There are already some indications of potential therapeutic benefits of the drug combinations in treating certain painful conditions, while still retaining the relative safety benefits of ibuprofen (at least at OTC dosages). The impact of natural products and Chinese Medicines on the safety of ibuprofen is also reviewed. The book is written in a more general style, including explanatory diagrams, for anyone interested in the properties, actions and uses of ibuprofen. 
650 0 |a Medicine. 
650 0 |a Immunology. 
650 0 |a Pharmacology. 
650 0 |a Rheumatology. 
650 1 4 |a Biomedicine. 
650 2 4 |a Pharmacology/Toxicology. 
650 2 4 |a Immunology. 
650 2 4 |a Rheumatology. 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer eBooks 
776 0 8 |i Printed edition:  |z 9783034804950 
856 4 0 |u http://dx.doi.org/10.1007/978-3-0348-0496-7  |z Full Text via HEAL-Link 
912 |a ZDB-2-SBL 
950 |a Biomedical and Life Sciences (Springer-11642)