Ibuprofen: Pharmacology, Therapeutics and Side Effects

• Main Author: Rainsford, K. D. (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Basel : Springer Basel : Imprint: Springer, 2012.
• Subjects: Medicine.; Immunology.; Pharmacology.; Rheumatology.; Biomedicine.; Pharmacology/Toxicology.

Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions, even in a low-dose form for over-the-counter (OTC), non-prescription sale. Over the past 40 years, ibuprofen has been proven to be as safe or safer and just as...

Table of Contents:

• Introduction
• Biodisposition in relation to actions
• Mechanisms of inflammation and sites of action of NSAIDs
• Clinical efficacy
• Drug derivatives and formulations
• General safety profile
• Gastro-intestinal toxicity
• Cardiovascular safety
• Renal toxicity
• Hepatic toxicity
• Other adverse reactions
• Global assessment of adverse reactions & human toxicology
• Overall assessment.