Tamoxifen Pioneering Medicine in Breast Cancer /

• Main Authors: Maximov, Philipp Y. (Author), McDaniel, Russell E. (Author), Jordan, V. Craig (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Basel : Springer Basel : Imprint: Springer, 2013.
• Series: Milestones in Drug Therapy
• Subjects: Medicine.; Cancer research.; Pharmacology.; Endocrinology.; Oncology.; Biomedicine.; Cancer Research.; Pharmacology/Toxicology.

Tamoxifen is a pioneering medicine for the treatment and prevention of breast cancer. It is the first drug targeted therapy in cancer to be successful. Tamoxifen targets the tumor estrogen receptor. The therapy is known to have saved the lives of millions of women over the past 40 years. This monogr...

Table of Contents:

• Discovery and Pharmacology of Nonsteroidal Estrogens and Antiestrogens
• Tamoxifen Goes Forward Alone
• Metabolites of Tamoxifen as the Basis of Drug Development
• Adjuvant Therapy – The Breakthrough
• The Wisconsin Story in the 1980’s: Discovery of Target Site Specific Estrogen Action
• Carcinogenesis and Tamoxifen
• Chemoprevention: Cinderella waiting for the ball
• Tamoxifen and Raloxifene head to head: The STAR TRIAL
• Acquired resistance to Tamoxifen: back to the beginning
• The legacy of Tamoxifen
• Appendix: Four decades of discovery in breast cancer research and treatment – an interview with V. Craig Jordan by Marc Poirot
• Selected Awards that Recognize the Contribution of Tamoxifen and Raloxifene to Medicine.