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03009nam a22004935i 4500 |
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978-3-0348-0682-4 |
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DE-He213 |
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20151103123248.0 |
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cr nn 008mamaa |
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130709s2013 sz | s |||| 0|eng d |
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|a 9783034806824
|9 978-3-0348-0682-4
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|a 10.1007/978-3-0348-0682-4
|2 doi
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|a QD431-431.7
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|a PSBZ
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|a SCI007000
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|a 572.6
|2 23
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| 100 |
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|a Castellano, Immacolata.
|e author.
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|a Gamma-Glutamyl Transpeptidases
|h [electronic resource] :
|b Structure and Function /
|c by Immacolata Castellano, Antonello Merlino.
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| 264 |
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|a Basel :
|b Springer Basel :
|b Imprint: Springer,
|c 2013.
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| 300 |
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|a VIII, 57 p. 28 illus., 18 illus. in color.
|b online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
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|a online resource
|b cr
|2 rdacarrier
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|a text file
|b PDF
|2 rda
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|a SpringerBriefs in Biochemistry and Molecular Biology,
|x 2211-9353
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|a 1 Introduction -- 2 Occurrence, genes and gene expression -- 3 Structure and function of γ-GTs -- 4 Autoprocessing and reaction mechanism of γ-GTs -- 5 γ-GT in bioclinical -- 6 γ-GTs: biotechnological and biomedical applications -- 7 Conclusions -- References.
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|a Gamma-Glutamyl Transpeptidases (γ-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the γ-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released γ-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). γ-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.γ-GT is upregulated during inflammation and in several human tumors, and it is involved in many physiological disorders related to oxidative stress, such as Parkinson’s disease and diabetes. Furthermore, this enzyme is used as a marker of liver disease and cancer. This book covers current knowledge about the structure-function relationship of γ-GTs and gives information about applications of γ-GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine.
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|a Life sciences.
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| 650 |
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|a Human physiology.
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| 650 |
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|a Biochemical engineering.
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| 650 |
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|a Enzymology.
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4 |
|a Life Sciences.
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| 650 |
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|a Enzymology.
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| 650 |
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|a Human Physiology.
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| 650 |
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|a Biochemical Engineering.
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| 700 |
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|a Merlino, Antonello.
|e author.
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| 710 |
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|a SpringerLink (Online service)
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|t Springer eBooks
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| 776 |
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|i Printed edition:
|z 9783034806817
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| 830 |
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|a SpringerBriefs in Biochemistry and Molecular Biology,
|x 2211-9353
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| 856 |
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|u http://dx.doi.org/10.1007/978-3-0348-0682-4
|z Full Text via HEAL-Link
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| 912 |
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|a ZDB-2-SBL
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| 950 |
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|a Biomedical and Life Sciences (Springer-11642)
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