T Lymphocytes as Tools in Diagnostics and Immunotoxicology

This book summarizes the state-of-the art in the development of T cell-based in vitro assays, which offer useful tools for hazard identification, risk assessment and improvement of diagnostics. It will be of interest to scientists, the chemical and pharmaceutical industry, and regulators involved in...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
Άλλοι συγγραφείς: Martin, Stefan F. (Επιμελητής έκδοσης)
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Basel : Springer Basel : Imprint: Springer, 2014.
Σειρά:Experientia Supplementum, 104
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
Πίνακας περιεχομένων:
  • The use of T cells in Hazard Characterization of Chemical and Drug Allergens and integration in testing strategies
  • Activation of the TCR complex by peptide-MHC and superantigens
  • Activation of the TCR complex by small chemical compounds
  • T Cell Responses to Contact Allergens
  • Contact hypersensitivity: Quantitative aspects, susceptibility and risk factors
  • Tools and methods for identification and analysis of rare antigen-specific T lymphocytes
  • Human T cell priming assay. Depletion of peripheral blood lymphocytes in CD25+ cells improves the in vitro detection of weak allergen-specific T cells
  • Correlation of contact sensitizer potency with T cell frequency and TCR repertoire diversity
  • On the role of co-inhibitory molecules in dendritic cell – T helper cell co-culture assays aimed to detect chemical induced contact allergy
  • T cell responses to drugs and drug metabolites
  • Hypersensitivity reactions to betalactams.