The Epothilones: An Outstanding Family of Anti-Tumor Agents From Soil to the Clinic /

• Κύριοι συγγραφείς: Altmann, K.- H. (Συγγραφέας), Höfle, G. (Συγγραφέας), Müller, R. (Συγγραφέας), Mulzer, J. (Συγγραφέας), Prantz, K. (Συγγραφέας)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Vienna : Springer Vienna, 2009.
• Σειρά: Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products, 90
• Θέματα: Chemistry.; Biotechnology.; Organic chemistry.; Bioorganic chemistry.; Chemical engineering.; Medicinal chemistry.; Organic Chemistry.; Medicinal Chemistry.; Industrial Chemistry/Chemical Engineering.; Bioorganic Chemistry.

Epothilones have received unusual attention over the past ten years. They are novel antitumor drugs which very much like their predecessor paclitaxel (Taxol) act via microtubule stabilization. In comparison to paclitaxel and a number of alternative drugs with a similar mode of bioaction (e.g. laulim...

Πίνακας περιεχομένων:

• General Aspects
• Biosynthesis and Heterologous Production of Epothilones
• Total Synthesis of Epothilones A-F
• Semisynthetic Derivatives of Epothilones
• Preclinical Pharmacology and Structure-Activity Studies of Epothilones
• Clinical Studies with Epothilones.