Metallointercalators Synthesis and Techniques to Probe Their Interactions with Biomolecules /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Aldrich-Wright, Janice (Editor)
• Format: Electronic eBook
• Language: English
• Published: Vienna : Springer Vienna : Imprint: Springer, 2011.
• Subjects: Chemistry.; Pharmacy.; Spectroscopy.; Inorganic chemistry.; Physical chemistry.; Biochemistry.; Inorganic Chemistry.; Biochemistry, general.; Physical Chemistry.; Spectroscopy/Spectrometry.

A comprehensive treatment of the characterisation techniques used in investigating inorganic and organic molecules that interact with biomolecules is presented to the reader in a clear fashion. The work consists of two parts: (i) synthetic aspects of metallointercalators along with targeting and imp...

Table of Contents:

• Introduction
• Synthesis:Platinum Intercalating Complexes; Binuclear Platinum Complexes;Binuclear Ruthenium and Platinum Intercalating Complexes; Sequence Selective Intercalating Complexes; Targeting and Improving Transport, Cucurbit[n]uril, Cylcodextrin and Dendrimers
• Techniques to Probe Interactions with Biomolecules:Introduction to NMR; DNA-NMR; PGSE-NMR; DNA ESI-MS; Investigating Binding Interactions using Linear Dichromism and Circular Dichromism; Flourescence Spectroscopy; Confocal Microscopy; Implementation of synchotron X-ray microscopy for investigations of the cellular uptake and cellular metabolism of metallointercalators; Biomolecular Helical Structure; Viscosity, TGA and Dialysis; Microarrays; Cytotoxicity-Cell lines; Antibacterical activity; Animal testing.