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02895nam a22004815i 4500 |
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978-3-319-00702-1 |
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DE-He213 |
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20151218121419.0 |
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|a 9783319007021
|9 978-3-319-00702-1
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|a 10.1007/978-3-319-00702-1
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|a Escribano Cuesta, Ana.
|e author.
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|a New Gold-Catalyzed Reactions and Applications for the Synthesis of Alkaloids
|h [electronic resource] /
|c by Ana Escribano Cuesta.
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|a Cham :
|b Springer International Publishing :
|b Imprint: Springer,
|c 2013.
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|a XIII, 195 p.
|b online resource.
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|a text
|b txt
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|a text file
|b PDF
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|a Springer Theses, Recognizing Outstanding Ph.D. Research,
|x 2190-5053
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|a Introduction -- General Objectives -- Gold(I)-Catalyzed Reactions of 1,6-Enynes with Aldehydes: Cycloaddition versus Metathesis-Type Reactions -- Formation of Cyclobutene Compounds via Gold(I)-Catalyzed Cycloisomerization of 1,n-Enynes -- Approach Toward the Total Synthesis of Lundurines.
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|a Ana Escribano Cuesta's thesis presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1,6-enynes using gold (I) complexes. An important part of the work involved streamlining the variables that allow the selective synthesis of different products such as tricyclic compounds, dihydropyrans, 1,3-dienes or cyclobutenes. The second chapter highlights the importance and difficulties in synthesising a cyclobutene subunit and the author includes a detailed description of how the products were prepared. The final chapter outlines the synthesis of lundurines using methodology developed by the author's research group for intramolecular gold-catalyzed cyclization of indoles with alkynes. The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells. The work in this thesis has led to a number of publications in high-profile chemistry journals.
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|a Chemistry.
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|a Organic chemistry.
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|a Organometallic chemistry.
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|a Catalysis.
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|a Chemistry.
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|a Organometallic Chemistry.
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|a Catalysis.
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|a Organic Chemistry.
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|a SpringerLink (Online service)
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|t Springer eBooks
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|i Printed edition:
|z 9783319007014
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|a Springer Theses, Recognizing Outstanding Ph.D. Research,
|x 2190-5053
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|u http://dx.doi.org/10.1007/978-3-319-00702-1
|z Full Text via HEAL-Link
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|a ZDB-2-CMS
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|a Chemistry and Materials Science (Springer-11644)
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