Cerebrospinal Fluid in Clinical Neurology

• Corporate Author: SpringerLink (Online service)
• Other Authors: Deisenhammer, Florian (Editor), Sellebjerg, Finn (Editor), Teunissen, Charlotte E. (Editor), Tumani, Hayrettin (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2015.
• Subjects: Medicine.; Laboratory medicine.; Neurology.; Neurosurgery.; Pathology.; Medicine & Public Health.; Laboratory Medicine.

The cerebrospinal fluid (CSF) is an invaluable diagnostic tool in clinical neurology, not only in the evaluation of inflammatory, degenerative, and malignant diseases of the nervous system, but also in the diagnosis of all forms of cerebral and subarachnoidal bleedings. The CSF can be easily obtaine...

Table of Contents:

• 1. Introduction
• 2. History of CSF
• 3. Anatomy of CSF-related spaces
• 4. Physiology of CSF
• 4.1. CSF production
• 4.2. CSR resorption
• 4.3. Biological function of CSF
• 5. CSF collection
• 5.1. Techniques
• 5.2. Counter-indications and complications
• 5.3. Preanalytical aspects
• 6. Methods
• 6.1. Cell counts and cell staining
• 6.2. Glucose and Lactate
• 6.3. Proteins
• 6.4. Albumin
• 6.5. Immunoglobulins
• 6.6. Detection of infectious agents
• 6.7. Immunohistochemistry
• 6.8. Others (biomarkers)
• 7. CSF in clinical syndromes
• 7.1. Inflammatory disease of the CNS
• 7.1.1. Acute (bacterial, viral meningitis)
• 7.1.2. Chronic (MS)
• 7.2. Inflammatory diseases of the PNS
• 7.2.1. Acute (GBS, Neuroborreliosis)
• 7.2.2 Chronic (CIDP)
• 7.3. Neoplastic and paraneoplastic neurological disorders
• 7.4. Dementias and degenerative disorders
• 7.5. Cerebral bleedings
• 7.6. CSF rhinorrhoea and otorrhoea. 8. Guidelines.