Protein Conformational Dynamics

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Han, Ke-li (Επιμελητής έκδοσης), Zhang, Xin (Επιμελητής έκδοσης), Yang, Ming-jun (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2014.
• Σειρά: Advances in Experimental Medicine and Biology, 805
• Θέματα: Medicine.; Proteins.; Bioinformatics.; Computational biology.; Biomedicine.; Biomedicine general.; Protein Science.; Computer Appl. in Life Sciences.

This book discusses how biological molecules exert their function and regulate biological processes, with a clear focus on how conformational dynamics of proteins are critical in this respect. In the last decade, the advancements in computational biology, nuclear magnetic resonance including paramag...

Πίνακας περιεχομένων:

• Protein folding simulations by generalized-ensemble algorithms
• Application of Markov State Models to Simulate Long Timescale Dynamics of Biological Macromolecules
• Understanding protein dynamics using conformational ensembles
• Generative Models of Conformational Dynamics
• Generalized spring tensor models for protein fluctuation dynamics and conformation changes
• The Joys and Perils of Flexible Fitting
• Coarse-Grained Models of the Proteins Backbone Conformational Dynamics
• Simulating protein folding in different environmental conditions
• Simulating the peptide folding kinetic related spectra based on the Markov State Model
• The Dilemma of Conformational Dynamics in Enzyme Catalysis: Perspectives from Theory and Experiment
• Exploiting protein intrinsic flexibility in drug design
• NMR and computational methods in the structural and dynamic characterization of ligand-receptor interactions
• Molecular Dynamics Simulation of Membrane Proteins
• Free-energy landscape of intrinsically disordered proteins investigated by all-atom multicanonical molecular dynamics
• Coordination and control inside simple biomolecular machines
• Multi-state Targeting Machinery Govern the Fidelity and Efficiency of Protein Localization
• Molecular dynamics simulations of F1-ATPase
• Chemosensorial G-proteins-coupled receptors: a perspective from computational methods.