SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

• Κύριοι συγγραφείς: Inuzuka, Hiroyuki (Συγγραφέας), Wei, Wenyi (Συγγραφέας)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2014.
• Σειρά: SpringerBriefs in Cancer Research
• Θέματα: Medicine.; Cancer research.; Proteins.; Cell cycle.; Biomedicine.; Cancer Research.; Cell Cycle Analysis.; Protein Structure.

This SpringerBrief explores the physiological roles of Skp1-Cullin1-F-box Complex (SCF) and Anaphase Promoting Complex (APC) in normal cells and in tumor formation. These two related, multi-subunit E3 ubiquitin ligase enzymes, APC and SCF are thought to be the major driving forces governing proper c...

Πίνακας περιεχομένων:

• 1. Introduction
• 2. The Fbxw subclass of SCF E3 ubiquitin Ligases
• 3. The FbxL subclass of SCF E3 ubiquitin Ligases
• 4. The Fbxo subclass of SCF E3 ubiquitin Ligases
• 5. APC/Cdc20 and APC/Cdh1 E3 ubiquitin Ligases
• 6. Conclusions and Future Perspectives.