Etiology of Acute Leukemias in Children

• Corporate Author: SpringerLink (Online service)
• Other Authors: Mejía-Aranguré, Juan Manuel (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2016.
• Edition: 1st ed. 2016.
• Subjects: Medicine.; Hematology.; Oncology.; Pediatrics.; Epidemiology.; Medicine & Public Health.

Childhood acute leukemias are one of the main causes of death in children aged 1 to 14 years in some countries; and unfortunately, we have been unable to prevent it. Certainly, a good parcel of it is due to the poor understanding about its etiology. This book aims to describe the most important theo...

Table of Contents:

• 1. Acute leukemias - An introduction
• 2. Etiology and prevention of acute leukemias in children
• 3. Direct viral leukemogenesis hypothesis
• 4. Etiology of leukemia in children with Down syndrome
• 5. Origin of leukemia in children with Down syndrome
• 6. Model: Susceptibility, exposure and vulnerability period
• 7. Molecular origin of acute leukemias
• 8. When as environmental factor would be considered cause of acute leukemia in children
• 9. Early bone marrow hematopoietic differentiation in acute lymphoblastic leukemia.