Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases

• Corporate Author: SpringerLink (Online service)
• Other Authors: Oldstone, Michael B. A. (Editor), Rosen, Hugh (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2014.
• Series: Current Topics in Microbiology and Immunology, 378
• Subjects: Medicine.; Immunology.; Virology.; Infectious diseases.; Biomedicine.; Infectious Diseases.

This volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease. Initial chapters define the pathways to understand S1P signalin...

Table of Contents:

• The organization of the sphingosine-1-phosphate signaling system
• Structural biology of the S1P1 receptor
• Chemical and genetic tools to explore S1P biology
• S1P control of endothelial integrity
• Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleen
• Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule
• Sphingosine-1-phosphate and central nervous system
• RORs in autoimmune disease.