Spectroscopic and Mechanistic Studies of Dinuclear Metallohydrolases and Their Biomimetic Complexes

• Κύριος συγγραφέας: Daumann, Lena Josefine (Συγγραφέας)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2014.
• Σειρά: Springer Theses, Recognizing Outstanding Ph.D. Research,
• Θέματα: Chemistry.; Spectroscopy.; Biochemical engineering.; Enzymology.; Biochemical Engineering.; Spectroscopy/Spectrometry.

Lena Daumanns's thesis describes structural and functional studies of the enzyme Glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes. It also examines the properties of small mimics of this enzyme and related binuclear metallohydrolases such as the metallo-ß-lactamases to enhance our un...

Πίνακας περιεχομένων:

• Introduction
• Experimental
• Understanding the Overall Structure of GpdQ and Metal Binding
• Structural and Mechanistic Studies of Zn(II) Complexes as Phosphoesterase Models
• Mechanistic Studies of Cd(II) Complexes as Phosphoesterase and Metallo-β-lactamase Models
• Spectroscopic and Mechanistic Studies of Co(II) Phosphoesterase and Metallo-β-lactamase Biomimetics
• Asymmetric Zn(II) Complexes as Structural and Functional Models for GpdQ
• Immobilization of GpdQ and Related Models for Bioremedial Applications
• Conclusion and Outlook.