Dissecting Regulatory Interactions of RNA and Protein Combining Computation and High-throughput Experiments in Systems Biology /

• Main Author: Jens, Marvin (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2014.
• Series: Springer Theses, Recognizing Outstanding Ph.D. Research,
• Subjects: Engineering.; Gene expression.; Biochemistry.; Systems biology.; Biological systems.; Computational intelligence.; Computational Intelligence.; Biological Networks, Systems Biology.; Gene Expression.; Biochemistry, general.

The work described in this book is an excellent example of interdisciplinary research in systems biology. It shows how concepts and approaches from the field of physics can be efficiently used to answer biological questions, and reports on a novel methodology involving creative computer-based analys...

Table of Contents:

• Introduction
• Computational analysis of PAR-CLIP data
• Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR
• Binding site occupancy with competition interactions in equilibrium
• Circular RNAs are a large class of animal RNAs with regulatory potency
• Discussion
• Methods.