Modelling the Short QT Syndrome Gene Mutations And Their Role in Cardiac Arrhythmogenesis /

• Κύριος συγγραφέας: Adeniran, Ismail (Συγγραφέας)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2014.
• Σειρά: Springer Theses, Recognizing Outstanding Ph.D. Research,
• Θέματα: Physics.; Cardiology.; Cell membranes.; Systems biology.; Biological systems.; Statistical physics.; Dynamical systems.; Biological Networks, Systems Biology.; Membrane Biology.; Statistical Physics, Dynamical Systems and Complexity.; Numerical and Computational Physics.

The Short QT Syndrome (SQTS) is characterized by abbreviated QT intervals on the electrocardiogram, increased risk of cardiac arrhythmias and sudden death. Although several gene mutations have been identified in SQT patients, the role of these mutations in promoting arrhythmogenesis is still not com...

Πίνακας περιεχομένων:

• Ion Channels and the Action Potential
• Potassium Channels Implicated in the Short QT Syndrome
• The Short QT Syndrome
• Model Development
• Methods, Experimental Protocols and Mathematical Preliminaries
• Increased Vulnerability of the Human Ventricle to Re-entrant Excitation in HERG-linked SQT1
• Mathematically Modelling the Functional Consequences of the SQT2 Mutation
• Proarrhythmia in KCNJ2-linked Short QT Syndrome: Insights from Modelling
• Relationship between Electrical and Mechanical Systole in the Short QT Syndrome: Insights from Modelling
• Discussion and Conclusion.