Glutamate and ATP at the Interface of Metabolism and Signaling in the Brain

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Parpura, Vladimir (Επιμελητής έκδοσης), Schousboe, Arne (Επιμελητής έκδοσης), Verkhratsky, Alexei (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2014.
• Σειρά: Advances in Neurobiology, 11
• Θέματα: Medicine.; Neurosciences.; Neurobiology.; Biomedicine.

ATP was naturally selected very early on as the main source of biological energy, and thus became an indispensable feature of life on the Earth. This was a critical evolutionary choice because it shaped enzymatic systems to utilize ATP in energy-dependent reactions and necessitated an appearance of...

Πίνακας περιεχομένων:

• 1. Glutamate and ATP: The Crossroads of Signaling and Metabolism in the Brain
• 2. Glutamate Metabolism in the Brain Focusing on Astrocytes
• 3. Glycogenolysis and Purinergic Signaling
• 4. Purinergic and Glutamatergic Receptors on Astroglia
• 5. Regulated Exocytosis in Astrocytes Is as Slow as the Metabolic Availability of Gliotransmitters: Focus on Glutamate and ATP
• 6. Adenosine and Glutamate in Neuroglial Interaction: Implications for Circadian Disorders and Alcoholism
• 7. Purinergic Receptor Stimulation Decreases Ischemic Brain Damage By Energizing Astrocyte Mitochondria
• 8. Excitotoxicity and Mitochondrial Dysfunction Underlie Age-dependent Ischemic White Matter Injury
• 9. Role of Astrocytes in Delayed Neuronal Death: GLT-1 and its Novel Regulation by MicroRNAs
• 10. Ca2+ Signaling in Astrocytes and its Role in Ischemic Stroke
• 11. Pathological Potential of Astroglial Purinergic Receptors.