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03558nam a22005055i 4500 |
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978-3-319-10012-8 |
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DE-He213 |
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20151030081457.0 |
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cr nn 008mamaa |
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141122s2015 gw | s |||| 0|eng d |
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|a 9783319100128
|9 978-3-319-10012-8
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|a 10.1007/978-3-319-10012-8
|2 doi
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|a MED071000
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|a 615
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|a Inflammatory Disorders
|h [electronic resource] /
|c edited by Mieczyslaw Pokorski.
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|a Cham :
|b Springer International Publishing :
|b Imprint: Springer,
|c 2015.
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|a X, 67 p. 11 illus.
|b online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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|a text file
|b PDF
|2 rda
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|a Advances in Experimental Medicine and Biology,
|x 0065-2598 ;
|v 839
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|a Inhaled Corticosteroids Increase Siglec-5/14 Expression in Sputum Cells of COPD Patients -- Tregs and HLA-DR Expression in Sputum Cells of COPD Patients Treated with Tiotropium and Formoterol -- Inhalation of Macrolides: A Novel Approach to Treatment of Pulmonary Infections -- Influence of Denture Plaque Biofilm on Oral Mucosal Membrane in Patients with Chronic Obstructive Pulmonary Disease -- Biophysical Activity of Animal-Derived Exogenous Surfactants Mixed with Rifampicin -- Organic Changes in the Central Nervous System in Children on Chronic Inhaled Corticosteroid Therapy -- Stem Cell Experiments Moves into Clinic: New Hope for Children with Bronchopulmonary Dysplasia -- Soluble Ligand CD40 and Uric Acid as Markers of Atheromatosis in Patients with Obstructive Sleep Apnea -- Carotid Artery Intima-Media Thickness in Hypertensive Patients with Obstructive Sleep Apnea.
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|a The mechanistic basis of chronic inflammation remains unclear. The research sheds new light on the immune cells expressing the activation markers HLA-DR and regulatory T cells (Tregs) and the cells expressing Siglec receptors as being key players in the immune system responsiveness to antigens and thus in lung tissue damage of chronic inflammation. The results help understand the mechanisms of action of common drugs used in COPD, such as formoterol, tiotropium, or corticosteroids, and point to novel drug targets. The chapters also deal with brain damaging effects, by far unrecognized, of inhaled corticosteroid therapy, a time-proven management of chronic inflammatory airway conditions; asthma being a case in point. Novel methods, likely less producing side effects, of macrolide antibiotics administration by inhalation are discussed, emphasizing not only bacteriostatic but also anti-inflammatory action.
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| 650 |
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|a Medicine.
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| 650 |
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|a Pharmacology.
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|a General practice (Medicine).
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|a Health promotion.
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|a Respiratory organs
|x Diseases.
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|a Biomedicine.
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|a Pharmacology/Toxicology.
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|a General Practice / Family Medicine.
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| 650 |
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|a Health Promotion and Disease Prevention.
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| 650 |
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|a Pneumology/Respiratory System.
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| 700 |
1 |
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|a Pokorski, Mieczyslaw.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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|t Springer eBooks
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| 776 |
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|i Printed edition:
|z 9783319100111
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| 830 |
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|a Advances in Experimental Medicine and Biology,
|x 0065-2598 ;
|v 839
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1007/978-3-319-10012-8
|z Full Text via HEAL-Link
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| 912 |
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|a ZDB-2-SBL
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| 950 |
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|a Biomedical and Life Sciences (Springer-11642)
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