DNA Replication Control in Microbial Cell Factories

• Main Authors: Glinkowska, Monika (Author), Boss, Lidia (Author), Wegrzyn, Grzegorz (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2015.
• Series: SpringerBriefs in Microbiology,
• Subjects: Life sciences.; Microbiology.; Cell biology.; Life Sciences.; Applied Microbiology.; Cell Biology.

This work describes the current knowledge of biochemical mechanisms regulating initiation of DNA replication in Escherichia coli, which focuses on the control of  activity of the DnaA protein. Examples of direct linkages between DNA replication and other cellular processes are provided. In addition,...

Table of Contents:

• Introduction.- Coordinating duplication of genetic material with cell growth – current views and old questions.- Structural organization of cellular processes and the regulation of cell cycle
• The link between metabolism and DNA replication
• Transcriptional activation – the unsolved problem
• Activity of DnaA is inhibited by components of translation machinery
• Nucleoid-associated proteins modulate activity of the DnaA initiator
• Interaction of DnaA with acidic components of fluid cellular membrane regulates its nucleotide-bound status and binding to oriC
• Influence of DNA replication on cell structure and function
• Conclusions.