Genomic Instability and Cancer Metastasis Mechanisms, Emerging Themes, and Novel Therapeutic Strategies /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Maxwell, Chris (Επιμελητής έκδοσης), Roskelley, Cal (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2015.
• Σειρά: Cancer Metastasis - Biology and Treatment, 20
• Θέματα: Medicine.; Cancer research.; Molecular biology.; Life sciences.; Cell biology.; Biomedicine.; Cancer Research.; Biomedicine general.; Molecular Medicine.; Life Sciences, general.; Cell Biology.

Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse. This book connects cancer metastasis with genomic instability in a comprehensive manner....

Πίνακας περιεχομένων:

• Preface.- Cancer Metastasis: Tracking and Attacking a Moving Target.- The generation, detection, and prevention of genomic instability during cancer progression and metastasis.- DNA damage response pathways in cancer predisposition and progression.- Mathematical modeling for DNA repair, carcinogenesis and cancer detection.- Animal models of metastasis.- Microenvironmental Control Of Metastatic Progression.- 7 Mechanotransduction, metastasis and genomic instability
• 8 Immunomodulation and Genomic Instability
• 9 Synthetic Genetic Approaches in Colorectal Cancer: Exploiting and Targeting Genome Instability
• Nanomedicine – Nanoparticles in Cancer Imaging and Therapy
• Index.