Neuroanatomy and Pathology of Sporadic Alzheimer's Disease

• Κύριοι συγγραφείς: Braak, Heiko (Συγγραφέας), Del Tredici, Kelly (Συγγραφέας)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2015.
• Σειρά: Advances in Anatomy, Embryology and Cell Biology, 215
• Θέματα: Medicine.; Neurosciences.; Geriatrics.; Pathology.; Biomedicine.; Geriatrics/Gerontology.

As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. T...

Πίνακας περιεχομένων:

• Prologue
• General Morphology of Alzheimer-associated intraneuronal pathology
• Consistent and systematic changes in the distribution pattern of intraneuronal inclusions render staging possible
• Basic organization of involved structures
• Presymptomatic stages
• General morphology of Alzheimer-associated extracellular pathology
• Symptomatic stages
• The progression of cortical lesions mimics the pattern of myelination in reverse order
• Tauopathies
• CSF biomarkers and imaging techniques
• The staging hypothesis: assumptions, challenges, potential
• Technical considerations.   .