Neuroanatomy and Pathology of Sporadic Alzheimer's Disease

• Main Authors: Braak, Heiko (Author), Del Tredici, Kelly (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2015.
• Series: Advances in Anatomy, Embryology and Cell Biology, 215
• Subjects: Medicine.; Neurosciences.; Geriatrics.; Pathology.; Biomedicine.; Geriatrics/Gerontology.

As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. T...

Table of Contents:

• Prologue
• General Morphology of Alzheimer-associated intraneuronal pathology
• Consistent and systematic changes in the distribution pattern of intraneuronal inclusions render staging possible
• Basic organization of involved structures
• Presymptomatic stages
• General morphology of Alzheimer-associated extracellular pathology
• Symptomatic stages
• The progression of cortical lesions mimics the pattern of myelination in reverse order
• Tauopathies
• CSF biomarkers and imaging techniques
• The staging hypothesis: assumptions, challenges, potential
• Technical considerations.   .