Protein Kinase CK2 Cellular Function in Normal and Disease States

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Ahmed, Khalil (Επιμελητής έκδοσης), Issinger, Olaf-Georg (Επιμελητής έκδοσης), Szyszka, Ryszard (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2015.
• Σειρά: Advances in Biochemistry in Health and Disease ; 12
• Θέματα: Medicine.; Cancer research.; Proteins.; Apoptosis.; Biomedicine.; Cancer Research.; Protein Science.

The field of protein kinases has greatly impacted our understanding of the basic mechanisms in cell function. The field has also been a major focus of drug development that considers the broad reach of the protein kinase function under diverse conditions. One member of the kinome, protein kinase CK2...

Πίνακας περιεχομένων:

• 1. CK2 Suppression of Apoptosis
• 2. Structural Determinants of CK2 Regulation
• 3. Targeting Protein Kinase: CK2 Suppresses Pro-Survival Signaling Pathways and Growth of Gliobastoma
• 4. The Roles of CK2 in Drosophila Neurogenesis
• 5. Targeting the CK2 Subunit Interface: Challenge and Usefulness
• 6. CK2 in Wnt/β-catenin signaling and embryo development
• 7. Defective expression of CK2β promotes EMT and stemness properties both required for breast cancer progression
• 8. Chemical Biology Approaches to Identify CK2 Substrates and Perform Unbiased Evaluation of CK2 Inhibitors
• 9. Development of Screening Systems and Identification of Novel Potent Inhibitors of Human Protein Kinase CK2
• 10. Protein Kinase CK2: At the Crossroad of Regulatory Cellular Pathways
• 11. Functional Regulation of DYRK Family Protein Kinases by Cellular Binding Partners
• 12. Regulation of CK2 in pancreatic β cells
• 13. Recent impressions from the configurational and conformational space captured by protein kinase CK2
• 14. Role of CK2 in Plant Responses to Abiotic Stress
• 15. “Genuine” Casein Kinase: The False Sister of CK2: Phosphorylates-Secreted Proteins
• 16. CK2: – A Novel Player in L-DOPA induced dyskinesia in a mouse model of Parkinson’s disease
• 17. CK2 function in the regulation of Akt Pathway: new findings and perspectives
• 18. CK2 structure from yeast to human
• 19. Cellular zinc signaling is triggered by CK2
• 20. A Nanomedicine Approach to Targeting CK2 for Cancer therapy
• 21. Bisubstrate approach for construction of high-affinity inhibitors and optical probes for protein kinase CK2.