Protein Homology Detection Through Alignment of Markov Random Fields Using MRFalign /

• Main Authors: Xu, Jinbo (Author), Wang, Sheng (Author), Ma, Jianzhu (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2015.
• Series: SpringerBriefs in Computer Science,
• Subjects: Computer science.; Mathematical statistics.; Bioinformatics.; Statistics.; Computer Science.; Computational Biology/Bioinformatics.; Probability and Statistics in Computer Science.; Statistics for Life Sciences, Medicine, Health Sciences.

This work covers sequence-based protein homology detection, a fundamental and challenging bioinformatics problem with a variety of real-world applications. The text first surveys a few popular homology detection methods, such as Position-Specific Scoring Matrix (PSSM) and Hidden Markov Model (HMM) b...