Histone Recognition

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Zhou, Ming-Ming (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2015.
• Θέματα: Medicine.; Gene expression.; Medical genetics.; Proteins.; Posttranslational modification.; Biomedicine.; Gene Expression.; Posttranslational Modification.; Protein-Ligand Interactions.; Gene Function.

This book provides a timely review of the role of histone modifications in epigenetic control of gene expression. Topics covered include: basic mechanisms of molecular recognition of histone post-translational modification (PTMs); combinatorial readout of histone PTMs by tandem epigenome reader doma...

Πίνακας περιεχομένων:

• The Bromodomain as the Acetyl-Lysine Binding Domain in Gene Transcription
• PHD Fingers as Histone Readers
• Methyl-Lysine Recognition by the Royal Family Modules: Chromo, Tudor, MBT, Chromo Barrel, and PWWP Domains
• Histone Recognition by WD40 Proteins
• Methyl-Lys Recognition by Ankyrin Repeat Proteins
• Methyl-Arginine Recognition by Tudor Domains
• Histone Recognition by Tandem Modules and Modulation by Multiple PTMs
• Genome-Wide Profiling of Molecular Recognition of Histone PTMs
• BET Bromodomain Inhibition as a Therapeutic Approach in Hematological Malignancies
• Anti-Inflammatory Effects of BET Protein Inhibition Through Modulation of Gene Transcription
• Activating Latent HIV by Inhibiting Bromodomain Proteins
• Small Molecule Modulation of Methyl-Lysine Mediated Interactions.