The Future of HIV-1 Therapeutics Resistance Is Futile? /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Torbett, Bruce E. (Editor), Goodsell, David S. (Editor), Richman, Douglas D. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2015.
• Series: Current Topics in Microbiology and Immunology, 389
• Subjects: Medicine.; Drug resistance.; Virology.; Infectious diseases.; Biomedicine.; Drug Resistance.; Infectious Diseases.

This volume thoroughly covers HIV-1 antiretrovirals currently in clinical use, together with their advantages and limitations. HIV-1 inhibitor resistance is discussed in detail, and critical assessments as to what will be required of future antiretrovirals in order to halt viral replication, reduce...

Table of Contents:

• HIV Therapy ­ Looking Towards the Future
• Computational challenges of structure-based approaches applied to HIV
• Nucleocapsid Protein: A Desirable Target For Future Therapies Against HIV-1
• HIV-1 integrase multimerization as a therapeutic target
• Targeting HIV transcription: The quest for a functional cure
• Targeting the HIV RNA Genome: High-Hanging Fruit Only Needs a Longer Ladder
• HIV-1 Gag: An Emerging Target for Antiretroviral Therapy
• The Triple Threat of HIV-1 Protease Inhibitors
• Illustrations of the HIV Life Cycle.