Nuclear Receptors: From Structure to the Clinic

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: McEwan, Iain J. (Επιμελητής έκδοσης), Kumar, Raj (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2015.
• Έκδοση: 1st ed. 2015.
• Θέματα: Medicine.; Human genetics.; Human physiology.; Endocrinology.; Biomedicine.; Human Genetics.; Human Physiology.

Nuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear recepto...

Πίνακας περιεχομένων:

• 1. Twenty-five Years of Nuclear Receptor Structure Analysis: From the Laboratory to the Clinic
• Part A. ALLOSTERIC REGULATION AND NUCLEAR RECEPTOR COMPLEX DYNAMICS. -2. Corticosteroid Receptors
• 3. Glucocorticoid Receptor Structure and Function
• 4. What Determines the Difference in DNA Binding Between the Androgen and the Glucocorticoid Receptors?
• 5. Allosteric Regulation and Intrinsic Disorder in Nuclear Hormone Receptors
• 6. Structural Analyses of Ordered and Disordered Regions in Ecdysteroid Receptor
• 7. Structural Analysis of Heterodimeric Nuclear Receptors
• Part B. NUCLEAR RECEPTOR CO-REGULATORY PROTEIN INTERACTIONS
• 8. Primate-specific Multi-functional Androgen Receptor Coregulator and Proto-oncogene Melanoma Antigen-A11 (MAGE-A11)
• 9. Assembly and Regulation of Nuclear Receptor Corepressor Complexes
• Part C. TAKING NUCLEAR RECEPTOR STRUCTURE INTO THE CLINIC
• 10. Thinking Outside the Box: Alternative Binding Sites in the Ligand Binding Domain of Nuclear Receptors
• 11. Selective Estrogen Receptor Modulators (SERMs) and Selective Androgen Receptor Modulators (SARMs).